A critical role of transcription factor YY1 in rheumatoid arthritis by regulation of interleukin-6

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• 作者：Jinpiao Lin^a ; ^b ; Yujue He^a ; ^b ; Junmin Chen^c ; Zhiyong Zeng^c ; Bin Yang^a ; ^b ; Qishui Ou^a ; ^b ; ^{ouqishuify@163.com}
• 关键词：Rheumatoid arthritis ; YY1 ; Transcription factor ; IL-6 ; Th17
• 刊名：Journal of Autoimmunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：77
• 期：Complete
• 页码：67-75
• 全文大小：2138 K
• 卷排序：77

文摘

Identified YY1 was over-expressed in RA patients and CIA mice firstly. Blocking YY1 ameliorated disease progression in CIA mice. Blocking YY1 inhibited IL-6 signaling and JAK/Stat signaling pathway. YY1 regulated Th17 and Treg balance via IL-6 signaling pathway in RA. YY1 positively regulated IL-6 transcription by binding to the promoter region of the IL-6.