Virus-like particles displaying H5, H7, H9 hemagglutinins and N1 neuraminidase elicit protective immunity to heterologous avian influenza viruses in chickens

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• 作者：Peter Pushko^a ; ^{ppushko@medigen-usa.com} ; Irina Tretyakova^a ; Rachmat Hidajat^a ; Aniko Zsak^b ; Klaudia Chrzastek^b ; Terrence M. Tumpey^c ; Darrell R. Kapczynski^b
• 关键词：Influenza ; Avian flu ; Vaccine ; Recombinant ; Virus-like particle ; VLP
• 刊名：Virology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：501
• 期：Complete
• 页码：176-182
• 全文大小：1181 K
• 卷排序：501

文摘

VLPs were prepared that co-localized H5, H7 and H9 subtypes in a VLP envelope. VLPs were characterized including electron microscopy, HA assay and NA enzyme activity. Experimental VLP vaccine was evaluated in an avian influenza challenge model. VLPs induced immune responses against heterologous H5, H7 and H9 virus challenges.