Comparative studies of infectivity, immunogenicity and cross-protective efficacy of live attenuated influenza vaccines containing nucleoprotein from cold-adapted or wild-type influenza virus in a mouse model

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• 作者：Irina Isakova-Sivak^a ; ¹ ; ^{isakova.sivak@gmail.com} ; Daniil Korenkov^a ; ¹ ; Tatiana Smolonogina^a ; Tatiana Tretiak^a ; Svetlana Donina^a ; Andrey Rekstin^a ; Anatoly Naykhin^a ; Svetlana Shcherbik^b ; Nicholas Pearce^b ; Li-Mei Chen^b ; Tatiana Bousse^b ; Larisa Rudenko^a
• 关键词：Live attenuated influenza vaccine ; Nucleoprotein ; Immunogenicity ; Cell-mediated immunity ; Cross-protection ; Mouse model ; Immunodominant epitope
• 刊名：Virology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：500
• 期：Complete
• 页码：209-217
• 全文大小：1432 K
• 卷排序：500

文摘

NP-specific CTL response to 6:2 LAIV might be outdated; Inclusion of wild-type NP (5:3 genotype) improves cross-protection of LAIV; Wild-type NP has little or no impact on biological features of LAIV. We recommend generating 5:3 reassortants for PR8-based IIV to improve CTL response.