Clinical translation of polymyxin-based combination therapy: Facts, challenges and future opportunities

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• 作者：Xueli Zhang^a ; Fengmei Guo^b ; Hua Shao^a ; ^{gycsh@163.com} ; Xiao Zheng^c ; ^{happyzxzx@126.com}
• 关键词：Polymyxins ; Combination therapy ; Multidrug resistance ; Clinical translation
• 刊名：Journal of Infection
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：74
• 期：2
• 页码：118-130
• 全文大小：412 K
• 卷排序：74

文摘

Combination therapy is sought as a potential measure to combat polymyxin resistance. Current findings are mixed and a clinically useful combination is yet to be defined. The factors and ambiguities that hinder the clinical translation are examined. Future research priorities to facilitate the clinical translation are discussed.