Ex Vivo CD34⁺-Selected T Cell-Depleted Peripheral Blood Stem Cell Grafts for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia and Myelodysplastic Syndrome Is Associated with Low Incidence of Acute and Chronic Graft-versus-Host Disease and High Treatment Response

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• 作者：Pere Barba¹ ; ² ; Patrick Hilden³ ; Sean M. Devlin³ ; Molly Maloy¹ ; Djamilia Dierov¹ ; Jimmy Nieves¹ ; Matthew D. Garrett¹ ; Julie Sogani¹ ; Christina Cho¹ ; Juliet N. Barker¹ ; ⁴ ; Nancy A. Kernan⁵ ; Hugo Castro-Malaspina¹ ; ⁴ ; Ann A. Jakubowski¹ ; ⁴ ; Guenther Koehne¹ ; ⁴ ; Esperanza B. Papadopoulos¹ ; ⁴ ; Susan Prockop⁵ ; Craig Sauter¹ ; ⁴ ; Roni Tamari¹ ; ⁴ ; Marcel R.M. van den Brink¹ ; ⁴ ; Scott T. Avecilla⁶ ; Richard Meagher⁶ ; Richard J. O'Reilly⁵ ; Jenna D. Goldberg¹ ; ⁴ ; James W. Young¹ ; ⁴ ; Sergio Giralt¹ ; ⁴ ; Miguel-Angel Perales¹ ; ⁴ ; Doris M. Ponce¹ ; ⁴ ; ^{ponced@mskcc.org}
• 关键词：T cell&ndash ; depleted transplantation ; Acute graft-versus-host disease ; Chronic graft-versus-host disease
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：23
• 期：3
• 页码：452-458
• 全文大小：553 K
• 卷排序：23

文摘

The day 180 incidence of grades II to IV acute graft-versus-host disease and the 3-year incidence of chronic graft-versus-host disease were low after ex vivo CD34+–selected T cell–depleted allogeneic hematopoietic stem cell transplantation Acute graft-versus-host disease therapy response was high in the ex vivo CD34+–selected T cell–depleted allograft recipients The 1-year and 3-year probabilities of chronic graft-versus-host disease–free/relapse-free survival were high after ex vivo CD34+–selected T cell–depleted allogeneic hematopoietic stem cell transplantation Ex vivo CD34+–selected T cell depletion is a calcineurin inhibitor–free strategy for the prevention of acute and chronic graft-versus-host disease in patients with acute leukemia and myelodysplastic syndrome