Chlamydia suis and Chlamydia trachomatis induce multifunctional CD4 T cells in pigs

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• 作者：T. Kä ; ser^a ; ^b ; ^{tekaeser@ncsu.edu} ; J.A. Pasternak^a ; M. Delgado-Ortega^a ; G. Hamonic^a ; K. Lai^a ; J. Erickson^a ; S. Walker^a ; J.R. Dillon^a ; V. Gerdts^a ; F. Meurens^c ; ^d
• 关键词：Chlamydia suis ; Chlamydia trachomatis ; Animal model ; Swine ; Vaccine development ; One Health
• 刊名：Vaccine
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：35
• 期：1
• 页码：91-100
• 全文大小：659 K
• 卷排序：35

文摘

Uterine Chlamydia suis and C. trachomatis infections induce strong pathology in pigs. Precise analysis of the adaptive immune response to porcine chlamydia infections. C. suis and C. trachomatis induce homo- and heterologous IFN-γ+TNF-α+ CD4 T cells. Potential for cross-protection between the two chlamydia species. Pigs represent a valuable large animal model for vaccine development.