Expression of interleukin-6 by a recombinant rabies virus enhances its immunogenicity as a potential vaccine

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• 作者：Jun Luo¹ ; Boyue Zhang¹ ; Yuting Wu¹ ; Qin Tian¹ ; Jing Zhao ; Ziyu Lyu ; Qiong Zhang ; Mingzhu Mei ; Yongwen Luo ; ^{ywluo@scau.edu.cn} ; Xiaofeng Guo ; ^{xfguo@scau.edu.cn}
• 关键词：Rabies virus ; HEP-Flury ; IL6 ; Vaccine ; Adjuvant
• 刊名：Vaccine
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：35
• 期：6
• 页码：938-944
• 全文大小：2042 K
• 卷排序：35

文摘

Recombinant rabies virus expressing interleukin-6 was rescued. Rabies virus expressing canine interleukin-6 induced stronger immune response in mice compared with parent strain. Interleukin-6 enhanced safety profile during the infection of rabies virus.