Structural and functional specificity of Influenza virus haemagglutinin and paramyxovirus fusion protein anchoring peptides

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• 作者：Larisa Kordyukova ^{kord@belozersky.msu.ru}
• 关键词：Influenza virus haemagglutinin ; Paramyxovirus fusion protein ; Anchoring peptide ; Transmembrane domain ; Cytoplasmic tail ; S-acylation (palmitoylation) ; Beta-branched amino acids ; Fusion ; Self-association of transmembrane domains
• 刊名：Virus Research
• 出版年：2017
• 出版时间：2 January 2017
• 年：2017
• 卷：227
• 期：Complete
• 页码：183-199
• 全文大小：3476 K
• 卷排序：227

文摘

Amino acids crucial for lipid membrane order/cholesterol binding are addressed. Influenza virus HA transmembrane domain (TMD): α-helical conformation. Paramyxovirus F TMD: β-strand rich conformation that promotes fusion. Influenza HA and paramyxovirus F TMD trimeric self-association is discussed. S-acylation (highly conserved in HA and occasional in F) is discussed in relation to fusion.