Risk Factors for and the Clinical Impact of Cytomegalovirus and Epstein-Barr Virus Infections in Pediatric Recipients of TCR-α/β- and CD19-Depleted Grafts

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• 作者：Alexandra Laberko¹ ; Anna Bogoyavlenskaya² ; Larisa Shelikhova² ; Zhanna Shekhovtsova² ; Dmitriy Balashov² ; Kirill Voronin³ ; Elena Kurnikova⁴ ; Elena Boyakova⁵ ; Elena Raykina⁶ ; Varvara Brilliantova⁶ ; Valentina Pirumova⁷ ; Galina Novichkova⁸ ; Alexei Maschan² ; Michael Maschan² ; ^{mmaschan@yandex.ru}
• 关键词：TCR-α/β depletion ; Immune recovery ; Cytomegalovirus ; Epstein-Barr virus ; Haploidentical ; Matched unrelated
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：23
• 期：3
• 页码：483-490
• 全文大小：692 K
• 卷排序：23

文摘

Incidence of CMV and EBV viremia is 51% and 33% in TCR-α/β–depleted transplantation. Neither CMV nor EBV viremia affects survival after TCR-α/β–depleted transplantation. CMV-seronegative donor–CMV-seropositive recipient combination should be avoided. Combined in vivo and ex vivo B cell depletion solves the problem of EBV PTLD. Graft-versus-host disease is associated with increased risk of CMV and EBV viremia.