STA-21, a STAT-3 inhibitor, attenuates the development and progression of inflammation in collagen antibody-induced arthritis

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• 作者：Sheikh Fayaz Ahmad^a ; ^{s_fayazahmad@yahoo.com} ; ^{fashaikh@ksu.edu.sa} ; Mushtaq Ahmad Ansari^a ; Ahmed Nadeem^a ; Khairy M.A. Zoheir^a ; ^b ; Saleh A. Bakheet^a ; Abdulaziz M.S. Alsaad^a ; Othman A. Al-Shabanah^a ; Sabry M. Attia^a ; ^c
• 关键词：5-Clone cocktail of monoclonal anti-type II collagen antibodies ; STA-21 ; Transcription factors ; Regulatory T cells ; Cytokines
• 刊名：Immunobiology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：222
• 期：2
• 页码：206-217
• 全文大小：4214 K
• 卷排序：222

文摘

STA-21 ameliorates CAIA by suppressing RORγt and upregulating of Foxp3. Treatment with STA-21 specifically regulates the JAK1/Stat3 pathway. STA-21 reduces CD8+ and CD14+ cells and increases IL-27+ cells. Action of STA-21 results in regulation of Th1 and Th2 cytokine levels. A Stat3 inhibitor may be a viable therapeutic option for rheumatoid arthritis.