BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins

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• 作者：Jennifer N. Rauch¹ ; Eric Tse² ; Rebecca Freilich¹ ; Sue-Ann Mok¹ ; Leah N. Makley¹ ; Daniel R. Southworth² ; Jason E. Gestwicki¹ ; ^{jason.gestwicki@ucsf.edu}
• 关键词：chaperones ; Hsp27 ; proteostasis ; intrinsically disordered proteins ; protein folding
• 刊名：Journal of Molecular Biology
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：429
• 期：1
• 页码：128-141
• 全文大小：1591 K
• 卷排序：429

文摘

BAG3 binds small heat shock proteins and Hsp70 at the same time. BAG3 reduces the size of small heat shock protein oligomers. BAG3 coordinates the ability of sHsp and Hsp70 refold denatured luciferase.