Preclinical Advances with Multiphoton Microscopy in Live Imaging of Skin Cancers

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• 作者：Thomas Yang Sun¹ ; ^{thomasyang.sun@yale.edu} ; Ann M. Haberman² ; Valentina Greco¹ ; ³ ; ^{Valentina.Greco@yale.edu}
• 关键词：MPM ; multiphoton microscopy
• 刊名：Journal of Investigative Dermatology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：137
• 期：2
• 页码：282-287
• 全文大小：998 K
• 卷排序：137

文摘

Conventional, static analyses have historically been the bedrock and tool of choice for the study of skin cancers. Over the past several years, in vivo imaging of tumors using multiphoton microscopy has emerged as a powerful preclinical tool for revealing detailed cellular behaviors from the earliest moments of tumor development to the final steps of metastasis. Multiphoton microscopy allows for deep tissue penetration with relatively minor phototoxicity, rendering it an effective tool for the long-term observation of tumor evolution. This review highlights some of the recent preclinical insights gained using multiphoton microscopy and suggests future advances that could enhance its power in revealing the mysteries of skin tumor biology.