ISG12a inhibits HCV replication and potentiates the anti-HCV activity of IFN-α through activation of the Jak/STAT signaling pathway independent of autophagy and apoptosis

详细信息    查看全文

• 作者：Yanzhao Chen^a ; Baihai Jiao^a ; Min Yao^a ; Xuezhen Shi^a ; Zhebin Zheng^b ; Shilin Li ; Dr.^a ; ^{shilin-li@hotmail.com} ; Limin Chen ; Dr.^a ; ^c ; ^{Limin_chen_99@yahoo.com}
• 关键词：ISG12a ; HCV ; IFN-α ; Jak/STAT ; Autophagy ; Apoptosis
• 刊名：Virus Research
• 出版年：2017
• 出版时间：2 January 2017
• 年：2017
• 卷：227
• 期：Complete
• 页码：231-239
• 全文大小：2620 K
• 卷排序：227

文摘

Overexpression of ISG12a inhibited HCV RNA replication both in Con1b replicon and the HCV JFH1-based cell culture system. ISG12a promoted the production of IFN α/β and activated the type I IFN signaling pathway. ISG12a potentiated the anti-HCV activity of IFN-α.