B cell and antibody responses in mice induced by a putative cell surface peptidase of Pneumocystis murina protect against experimental infection

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• 作者：Sanbao Ruan^a ; Yang Cai^b ; Alistair J. Ramsay^c ; David A. Welsh^a ; Karen Norris^d ; Judd E. Shellito^a ; ^{jshell@lsuhsc.edu}
• 关键词：P. murina ; Pneumocystis murina ; PC ; Pneumocystis (species not specified)
• 刊名：Vaccine
• 出版年：2017
• 出版时间：23 January 2017
• 年：2017
• 卷：35
• 期：4
• 页码：672-679
• 全文大小：1372 K
• 卷排序：35

文摘

A novel cell surface peptidase, SPD1, on Pneumocystis murina is identified. Immunization with SPD1 induces antibody and B cell responses. Immunization with SPD1 protects CD4 lymphocyte-deficient mice from Pneumocystis infection.