Comparison analysis of microRNAs in response to EV71 and CA16 infection in human bronchial epithelial cells by high-throughput sequencing to reveal differential infective mechanisms

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• 作者：Yajie Hu ; Jie Song ; Longding Liu ; Jing Li ; Beibei Tang ; Ying Zhang ; Jingjing Wang ; Lichun Wang ; Shengtao Fan ; Ming Feng ; Qihan Li ; ^{liqihan@imbcams.com.cn}
• 关键词：Enterovirus 71 (EV71) ; Coxsackievirus A16 (CA16) ; High-throughput sequencing ; MicroRNAs (miRNAs) ; Human bronchial epithelial (16HBE) cells
• 刊名：Virus Research
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：228
• 期：Complete
• 页码：90-101
• 全文大小：3923 K
• 卷排序：228

文摘

It was the first report to identify miRNAs that are differentially regulated following EV71 and CA16 infection in 16HBE cells by miRNA sequencing. Our results indicated that the distinct changes induced by EV71 and CA16 infection may be partly linked to airway epithelial barrier function. The 7 novel differentially expressed miRNAs in this study will provide additional insights into host-pathogen interactions and pathogenesis.