Comparative analysis of influenza A(H3N2) virus hemagglutinin specific IgG subclass and IgA responses in children and adults after influenza vaccination

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• 作者：Alessandro Manenti^a ; ¹ ; Sarah M. Tete^b ; ^c ; ^d ; ¹ ; ^{sarah.tete@uib.no} ; Kristin G.-I. Mohn^b ; ^c ; Å ; sne Jul-Larsen^b ; ^c ; ^d ; Elena Gianchecchi^e ; Emanuele Montomoli^a ; ^e ; Karl A. Brokstad^f ; Rebecca J. Cox^b ; ^c ; ^d ; ^{rebecca.cox@uib.no}
• 关键词：Influenza ; LAIV3 ; Live attenuated influenza vaccine ; IgA ; IgG subclass ; Antibody response
• 刊名：Vaccine
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：35
• 期：1
• 页码：191-198
• 全文大小：1079 K
• 卷排序：35

文摘

LAIV3 induced age-related hemagglutination inhibition antibody responses. IgG1 was the main IgG subclass detected followed by IgG3. Significant hemagglutinin-specific IgG1 and IgA1 response in children but not adults. LAIV3 and IIV3 induced IgG antibodies with comparable and significantly increased avidity.