Efficient dynamic kinetic resolution of arylamines with Pd/layered double-hydroxide-dodecyl sulfate anion for racemization

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• 作者：Gang Xu ; Xiaoting Dai ; Simin Fu ; Jianping Wu ; Lirong Yang
• 关键词：Racemization catalyst ; Dynamic kinetic resolution ; Arylamines ; Lipase
• 刊名：Tetrahedron Letters
• 出版年：8 January, 2014
• 年：2014
• 卷：55
• 期：2
• 页码：397-402
• 全文大小：3562 K

文摘

A novel and efficient racemization catalyst, Pd/layered double-hydroxide-dodecyl sulfate anion, was prepared and used in the dynamic kinetic resolution (DKR) of arylamines. The undesired enantiomer was completely racemized at 55 掳C, allowing the catalyst to be compatible with biocatalysts. DKR proceeded smoothly and showed a broad substrate scope, with good conversion and high product enantiomeric excesses (ee_p). The system could be reused more than 30 times without loss of conversion and ee_p value.