Modulation of HCV replication and translation by ErbB3 binding protein1 isoforms

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• 作者：Priya Mishra ; Updesh Dixit ; Ashutosh K. Pandey ; Alok Upadhyay ; Virendra N. Pandey ; ^{vnp22@njms.rutgers.edu}
• 关键词：ErbB3 binding protein1 ; HCV replication ; PKR activation ; Ebp1isoforms
• 刊名：Virology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：500
• 期：Complete
• 页码：35-49
• 全文大小：3020 K
• 卷排序：500

文摘

The p42 and p48 isoforms of Ebp1 affect HCV replication by modulation of PKR activation. PKR activation is promoted by p42 isoform, and inhibited by p48 isoform. Activated PKR strongly inhibits RdRp activity of HCV replicase.