Sixty years old is the breakpoint of human frontal cortex aging

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• 作者：Rosanna Cabré ; ^a ; ¹ ; ^{rosanna.cabre@mex.udl.cat} ; Alba Naudí ; ^a ; ¹ ; ^{alba.naudi@mex.udl.cat} ; Mayelin Dominguez-Gonzalez^b ; ^{mdominguezg@idibell.cat} ; Victò ; ria Ayala^a ; ^{victoria.ayala@mex.udl.cat} ; Mariona Jové ; ^a ; ^{mariona.jove@udl.cat} ; Natalia Mota-Martorell^a ; ^{natalia.mota@mex.udl.cat} ; Gerard Piñ ; ol-Ripoll^c ; ^{gpinol@gss.scs.es} ; Maria Pilar Gil-Villar^c ; ^{mapi.gil.villar@gmail.com} ; Montserrat Rué ; ^d ; ^{montse.rue@cmb.udl.cat} ; Manuel Portero-Otí ; n^a ; ^{manuel.portero@mex.udl.cat} ; Isidre Ferrer^b ; ^e ; ^{8082ifa@gmail.com} ; Reinald Pamplona^a ; ^{reinald.pamplona@mex.udl.cat}
• 关键词：Cell survival pathways ; Mechanistic target of rapamycin (mTOR) ; Mitochondria respiratory chain ; Mitochondrial stress ; Protein oxidation ; Repressor element 1-silencing transcription factor (REST)
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：14-22
• 全文大小：1884 K
• 卷排序：103

文摘

Protein damage increases during human brain aging, with a breakpoint at 60 years old. This trajectory is coincident with a decrease in the respiratory chain complexes. The deterioration in oxidative stress homeostasis induces an adaptive response.