Use of antimüllerian hormone to predict the menopausal transition in HIV-infected women

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• 作者：Rebecca Scherzer ; PhD^a ; ^d ; Ruth M. Greenblatt ; MD^a ; ^b ; ^c ; ^{ruth.greenblatt@ucsf.edu} ; Zaher O. Merhi ; MD^e ; Seble Kassaye ; MD ; MS^f ; Geralyn Lambert-Messerlian ; PhD^g ; Pauline M. Maki ; PhD^h ; Kerry Murphy ; MDⁱ ; Roksana Karim ; PhD^j ; Peter Bacchetti ; PhD^c
• 关键词：AIDS ; antim&uuml ; llerian hormone ; hepatitis C virus infection ; HIV ; menopause ; ovarian reserve ; viremia
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：216
• 期：1
• 页码：46.e1-46.e11
• 全文大小：364 K
• 卷排序：216

文摘

HIV infection has been associated with early menopausal onset, which may have adverse long-term health consequences. Antimüllerian hormone, a biomarker of ovarian reserve and gonadal aging, is reduced in HIV-infected women.ObjectiveWe sought to assess the relationship of antimüllerian hormone to age of menopause onset in HIV-infected women.Study DesignWe used antimüllerian hormone levels measured in plasma in 2461 HIV-infected participants from the Women’s Interagency HIV Study to model the age at final menstrual period. Multivariable normal mixture models for censored data were used to identify factors associated with age at final menstrual period.ResultsHigher antimüllerian hormone at age 40 years was associated with later age at final menstrual period, even after multivariable adjustment for smoking, CD4 cell count, plasma HIV RNA, hepatitis C infection, and history of clinical AIDS. Each doubling of antimüllerian hormone was associated with a 1.5-year increase in the age at final menstrual period. Median age at final menstrual period ranged from 45 years for those in the 10th percentile of antimüllerian hormone to 52 years for those in the 90th percentile. Other factors independently associated with earlier age at final menstrual period included smoking, hepatitis C infection, higher HIV RNA levels, and history of clinical AIDS.ConclusionAntimüllerian hormone is highly predictive of age at final menstrual period in HIV-infected women. Measuring antimüllerian hormone in HIV-infected women may enable clinicians to predict risk of early menopause, and potentially implement individualized treatment plans to prevent menopause-related comorbidities and to aid in interpretation of symptoms.