Methane ameliorates spinal cord ischemia-reperfusion injury in rats: Antioxidant, anti-inflammatory and anti-apoptotic activity mediated by Nrf2 activation

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• 作者：Liping Wang^a ; ¹ ; Ying Yao^b ; ¹ ; Rong He^c ; ¹ ; Yan Meng^b ; Na Li^b ; Dan Zhang^b ; Jiajun Xu^d ; Ouyang Chen^e ; Jin Cui^f ; Jinjun Bian^b ; Yan Zhang^b ; Guozhong Chen^a ; ^{cgzssq2000@sina.com} ; Xiaoming Deng^b ; ^{dengphd1@hotmail.com}
• 关键词：ARE ; antioxidant response element ; BSCB ; blood-spinal cord barrier ; CXCL1 ; C-X-C motif ligand 1 ; GFAP ; glial fibrillary acidic protein ; GSH ; glutathione ; GSSG ; glutathione disulfide ; HO-1 ; heme oxygenase-1 ; H2O2 ; hydrogen peroxide ; Iba-1 ; ionized calcium-binding adaptor molecule 1 ; ICAM-1 ; intercellular adhesion molecule 1 ; IL-1β ; interleukin 1β ; IR ; ischemia-reperfusion ; Keap1 ; kelch-like ECH-associated protein-1 ; MDA ; malondialdehyde ; MMP-9 ; matrix metallopeptidase-9 ; MPO ; myeloperoxidase ; MS
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：69-86
• 全文大小：4965 K
• 卷排序：103

文摘

Methane exerts neuroprotective effects on spinal cord ischemia-reperfusion injury. Methane activates Nrf2 in neurons, microglia and astrocytes in the spinal cord. The increased Nrf2 signaling inhibits oxidative stress and neuronal apoptosis. It also reduces proinflammatory response and blood-spinal cord barrier dysfunction. Our results elucidate Nrf2-dependent benefits of methane for spinal cord injury.