2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound

详细信息    查看全文

• 作者：Konstantina Filippopoulou^a ; Nikoletta Papaevgeniou^a ; ^c ; Maria Lefaki^a ; Anna Paraskevopoulou^a ; David Biedermann^b ; Vladimí ; r Křen^b ; Niki Chondrogianni^a ; ^{nikichon@eie.gr}
• 关键词：Aβ ; amyloid beta ; AD ; Alzheimer's disease ; DHS A/B ; 2 ; 3-dehydrosilybin A/B ; CHO ; Chinese hamster ovary ; CM ; conditioned medium ; FGT-1 ; facilitated glucose transporter isoform 1 ; GLUT ; IIS ; insulin/IGF-1 signaling ; IPTG ; Isopropyl-β-D-1-thiogalactopyranoside ; NBT ; nitro tetrazolium blue ; NRLB ; non-reducing Laemmli buffer ; NS ; not significant ; O2∙ &minus ; superoxide anions ; PMA ; phorbol myristate acetate ; RNAi ; RNA interference ; wt ; wild type
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：256-267
• 全文大小：1190 K
• 卷排序：103

文摘

2,3-dehydrosilybin A/B (DHS A/B) promotes lifespan extension in C. elegans. DHS A/B promotes resistance to stress in human cells and in C. elegans. DHS A/B exerts anti-aggregation properties in human cells and nematodes. DHS A/B leads to decelerated progression of Alzheimer's disease phenotype. DHS A/B outcomes in C. elegans are FGT-1- and DAF-16- dependent.