Is a hybrid strategy a lower-risk alternative to stage 1 Norwood operation?

详细信息    查看全文

• 作者：Travis J. Wilder ; MD^a ; Brian W. McCrindle ; MD^b ; ^{brian.mccrindle@sickkids.ca} ; Edward J. Hickey ; MD^c ; Gerhard Ziemer ; MD ; PhD^d ; Christo I. Tchervenkov ; MD^e ; Marshall L. Jacobs ; MD^f ; Peter J. Gruber ; MD ; PhD^g ; Eugene H. Blackstone ; MD^h ; William G. Williams ; MD^a ; William M. DeCampli ; MD ; PhDⁱ ; Christopher A. Caldarone ; MD^c ; Christian Pizarro ; MD^j ; for the Congenital Heart Surgeons' Society
• 关键词：congenital heart disease ; single ventricle ; critical left ventricular outflow tract obstruction ; hypoplastic left heart syndrome ; hybrid ; Norwood
• 刊名：The Journal of Thoracic and Cardiovascular Surgery
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：153
• 期：1
• 页码：163-172.e6
• 全文大小：1650 K
• 卷排序：153

文摘

For neonates with critical left ventricular outflow tract obstruction (LVOTO), hybrid procedures are an alternative to the Norwood stage 1 procedure. Despite perceived advantages, however, outcomes are not well defined. Therefore, we compared outcomes after stage 1 hybrid and Norwood procedures.MethodsIn a critical LVOTO inception cohort (2005-2014; 20 institutions), a total of 564 neonates underwent stage 1 palliation with the Norwood operation with a modified Blalock-Taussig shunt (NW-BT; n = 232; 41%), Norwood operation with a right ventricle–to–pulmonary artery conduit (NW-RVPA; n = 222; 39%), or a hybrid procedure (n = 110; 20%). Post–stage 1 outcomes were analyzed via competing-risks and parametric hazard analyses and compared among all 564 patients and between patients who underwent propensity-matched hybrid and those who underwent NW-BT/NW-RVPA.ResultsBy 6 years after the stage 1 operation, 50% ± 3%, 7% ± 2%, and 4% ± 1% of patients transitioned to Fontan, transplantation, and biventricular repair, respectively, whereas 7% ± 2% were alive without transition and 32% ± 2% died. Risk factors for death without transition included procedure type, smaller ascending aorta, aortic valve atresia, and lower birth weight. Risk-adjusted 4-year survival was better after NW-RVPA than after NW-BT or hybrid (76% vs 60% vs 61%; P < .001). Furthermore, for neonates with lower birth weight (<∼2 kg), an interaction between birth weight and hybrid resulted in a trend toward better survival after hybrid compared with NW-BT or NW-RVPA. For propensity-matched neonates between hybrid and NW-BT (88 pairs), 4-year survival was similar (62% vs 57%; P = .58). For propensity-matched neonates between hybrid and NW-RVPA (81 pairs), 4-year survival was better after NW-RVPA (59% vs 75%; P = .008).ConclusionsFor neonates with critical LVOTO undergoing single-ventricle palliation, NW-RVPA was associated with the best overall survival. Hybrid strategies are not a lower-risk alternative to Norwood operations overall; however, the impact of lower birth weight on survival may be mitigated after hybrid procedures compared with Norwood operations.