Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women

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• 作者：Christina Gosmann¹ ; ² ; Melis N. Anahtar¹ ; ² ; Scott A. Handley³ ; Mara Farcasanu¹ ; Galeb Abu-Ali⁴ ; Brittany A. Bowman¹ ; Nikita Padavattan⁵ ; Chandni Desai³ ; Lindsay Droit³ ; Amber Moodley⁶ ; Mary Dong¹ ; ⁶ ; Yuezhou Chen⁷ ; Nasreen Ismail⁵ ; Thumbi Ndung&rsquo ; u¹ ; ⁵ ; Musie S. Ghebremichael¹ ; ² ; Duane R. Wesemann⁷ ; Caroline Mitchell⁸ ; Krista L. Dong¹ ; ⁶ ; Curtis Huttenhower⁴ ; Bruce D. Walker¹ ; ⁹ ; ¹⁰ ; ¹¹ ; Herbert W. Virgin³ ; Douglas S. Kwon¹ ; ² ; ¹⁰ ; ¹² ; ^{dkwon@mgh.harvard.edu}
• 关键词：female genital tract (FGT) ; vaginal microbiome ; mucosal immunology ; HIV susceptibility ; sub-Saharan Africa ; HIV acquisition
• 刊名：Immunity
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：46
• 期：1
• 页码：29-37
• 全文大小：1838 K
• 卷排序：46

文摘

Women with high-diversity genital bacterial communities acquire HIV at 4× higher rates Activated mucosal CD4+ T cell numbers are elevated in women with high-risk bacteria Specific genital bacterial taxa are linked with reduced or elevated HIV acquisition I.vag administered Prevotella increases activated genital CD4+ T cell numbers in mice