Mesenchymal stem cells upregulate Treg cells via sHLA-G in SLE patients

详细信息    查看全文

• 作者：Chen Chen¹ ; Jun Liang¹ ; Genhong Yao ; Haifeng Chen ; Bingyu Shi ; Zhuoya Zhang ; Cheng Zhao ; Huayong Zhang ; Lingyun Sun ; ^{lingyunsun@nju.edu.cn}
• 关键词：Human leukocyte antigen-G ; SLE ; Mesenchymal stem cells ; Treg
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：44
• 期：Complete
• 页码：234-241
• 全文大小：1014 K
• 卷排序：44

文摘

Serum sHLA-G levels are correlated with creatinine in SLE patients. ILT2 expression on T and B lymphocytes was downregulated in SLE patients. Serum sHLA-G and mouse Qa-2 increased after MSCs transplantation. MSCs upregulated Treg cells via HLA-G/ILT2.