Cyclooxygenase-2 in glioblastoma multiforme

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• 作者：Jiange Qiu¹ ; ² ; Zhi Shi¹ ; ^{tshizhi@jnu.edu.cn} ; Jianxiong Jiang² ; ^{jianxiong.jiang@uc.edu}
• 刊名：Drug Discovery Today
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：22
• 期：1
• 页码：148-156
• 全文大小：1964 K
• 卷排序：22

文摘

Current treatment for glioblastoma fails to provide sufficient therapeutic outcomes. Overexpressed cyclooxygenase-2 (COX-2) contributes to the glioblastoma progression. COX-2 plays complex roles in glioma invasion, angiogenesis, immunosuppression, etc. COX-2 inhibitors sensitize glioblastomas to conventional chemo- and radio-therapies. COX-2 downstream signaling pathways might provide alternative targets for gliomas.