Emergence of colistin resistance in the largest university hospital complex of São Paulo, Brazil, over five years

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• 作者：Flá ; via Rossi^a ; ^b ; ^{flaviarossi61@gmail.com} ; Raquel Girardello^a ; ^b ; Ana Paula Cury^a ; ^b ; Thais Sabato Romano Di Gioia^a ; ^b ; Joã ; o Nó ; brega de Almeida Jr^a ; ^b ; Alberto José ; da Silva Duarte^b
• 关键词：Colistin-resistant ; Polymyxin B-resistant ; Enterobacteriaceae ; Brazil
• 刊名：The Brazilian Journal of Infectious Diseases
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：21
• 期：1
• 页码：98-101
• 全文大小：454 K
• 卷排序：21

文摘

Colistin resistance involving Gram-negative bacilli infections is a challenge for health institutions around of the world. Carbapenem-resistance among these isolates makes colistin the last therapeutic option for this treatment. Colistin resistance among Enterobacteriaceae, Acinetobacter spp., and Pseudomonas spp. was evaluated between 2010 and 2014 years, at Hospital das Clínicas, São Paulo, Brazil. Over five years 1346 (4.0%) colistin resistant Gram-negative bacilli were evaluated. Enterobacteriaceae was the most frequent (86.1%) pathogen isolated, followed by Acinetobacter spp. (7.6%), and Pseudomonas spp. (6.3%). By temporal analysis there was a trend for an increase of colistin resistance among Enterobacteriaceae, but not among non-fermentative isolates. Among 1346 colistin resistant isolates, carbapenem susceptibility was observed in 21.5%. Colistin resistance in our hospital has been alarmingly increased among Klebsiella pneumoniae isolates in both KPC positive and negative, thus becoming a therapeutic problem.