Effect of toad skin extracts on the pain behavior of cancer model mice and its peripheral mechanism of action

详细信息    查看全文

• 作者：Tao Chen^a ; ^b ; ¹ ; ^{chentao@ctgu.edu.cn} ; Shen-jun Yuan^a ; ¹ ; Xue-qin Yu^c ; Liang-bo Jiao^d ; Wei Hu^a ; ^b ; Wang-long Chen^a ; Bo Xie^a
• 关键词：Toad skin extracts ; Cancer pain ; β-endorphin ; μ-opioid receptor ; Tumor infiltrating lymphocytes ; Analgesic
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：42
• 期：Complete
• 页码：90-99
• 全文大小：2489 K
• 卷排序：42

文摘

TSE significantly relieved pain in cancer pain model mice and raised their pain threshold. TSE seems to play a prominent role in promoting the activity of TILs (CD3 + and CD8 + T cells). This immune-cell-derived peripheral analgesic pathway might have widespread potential for clinical use.