Curcumin ameliorates liver damage and progression of NASH in NASH-HCC mouse model possibly by modulating HMGB1-NF-κB translocation

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• 作者：Rejina Afrin^a ; Somasundaram Arumugam^a ; Azizur Rahman^b ; Mir Imam Ibne Wahed^a ; ^c ; Vengadeshprabhu Karuppagounder^a ; Meilei Harima^a ; Hiroshi Suzuki^a ; Shizuka Miyashita^a ; Kenji Suzuki^d ; Hiroyuki Yoneyama^e ; Kazuyuki Ueno^f ; Kenichi Watanabe^a ; ^{watanabe@nupals.ac.jp}
• 关键词：Curcumin ; Fibrosis ; HMGB1 ; NF-κB ; Non-alcoholic steatohepatitis ; Oxidative stress
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：44
• 期：Complete
• 页码：174-182
• 全文大小：1260 K
• 卷排序：44

文摘

NASH-HCC mouse model involves the increased HMGB1 and NF-κB translocation. In this model, oxidative stress and inflammation were significantly increased. It involves the activation of lipogenesis and fibrosis in NASH liver. Curcumin treatment reduced these oxidative stress, inflammation and lipogenesis. Curcumin markedly attenuated fibrosis, HMGB1-NF-κB translocation and its signaling.