GM-CSF and IL-4 produced by NKT cells inversely regulate IL-1β production by macrophages

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• 作者：Sehee Ahn^b ; ¹ ; Dongjin Jeong^b ; ¹ ; Sae Jin Oh^b ; ¹ ; Jiye Ahn^b ; Seung Hyo Lee^d ; Doo Hyun Chung^a ; ^b ; ^c ; ^{doohyun@snu.ac.kr}
• 关键词：NKT cells ; Macrophages ; IL-1b ; GM-CSF ; IL-4
• 刊名：Immunology Letters
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：182
• 期：Complete
• 页码：50-56
• 全文大小：1339 K
• 卷排序：182

文摘

NKT cells regulate macrophage production of IL-1β via cytokine production. Among cytokines secreted by NKT cells, GM-CSF and IL-4 inversely influence IL-1β production. GM-CSF regulates LPS-mediated pro-IL-1β expression and inflammasome activation. IL-4 enhances M2-polarization of macrophages thereby inhibits IL-1β production.