Serum periostin level is not associated with allergic rhinitis or allergic sensitization in Korean children

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• 作者：Dong Young Kim^a ; ¹ ; Jeong Hong Kim^a ; ^b ; ¹ ; Keun-Hwa Lee^b ; Seong-Chul Hong^b ; Hye-Sook Lee^b ; Ju Wan Kang^a ; ^c ; ^{juwankangmd@gmail.com}
• 关键词：Periostin ; Allergic rhinitis ; Allergic sensitization ; Children ; Korean
• 刊名：International Journal of Pediatric Otorhinolaryngology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：93
• 期：Complete
• 页码：24-29
• 全文大小：538 K
• 卷排序：93

文摘

Periostin is a matricellular protein, synthesized in the airway epithelium and induced by interleukin (IL)-4 and IL-13. The significance of periostin as a biomarker of T helper type 2 cell (Th2)-induced airway inflammation, and as a measure of the response to Th2-targeted therapy, has recently been highlighted. We explored the relationship between serum periostin and allergic rhinitis in Korean children.MethodsData for fifth and sixth grade children from six randomly selected elementary schools located in Jeju and Seogwipo City, Korea, were investigated. Serum periostin levels were determined by enzyme-linked immunosorbent assay. Sex, school grade, body mass index, and presence of allergic nasal symptoms were obtained via a self-reported survey and skin prick testing was performed.ResultsThere were no significant differences between groups, when stratification was applied according to sex, grade, presence of atopy, and presence of allergic nasal symptoms. Sex and body mass index were significantly associated with serum periostin levels in multivariate linear regression analysis. However, allergic rhinitis was not associated with serum periostin levels.ConclusionAllergic rhinitis or allergic sensitization in Korean children did not influence serum periostin levels. Further studies are required to investigate the significance of serum periostin levels in pediatric allergic rhinitis.