A case of clinical and microbiological failure of azithromycin therapy in Salmonella enterica serotype Typhi despite low azithromycin MIC

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• 作者：Abi Manesh^a ; ^{abimanesh@gmail.com} ; Veeraraghavan Balaji^b ; ^{vbalaji@cmcvellore.ac.in} ; Devanga Ragupathi Naveen Kumar^b ; ^{speed.naveen1@gmail.com} ; Priscilla Rupali^a ; ^{prisci@cmcvellore.ac.in}
• 关键词：Azithromycin ; Salmonella enterica serotype Typhi ; clinical failure ; MIC within susceptible range
• 刊名：International Journal of Infectious Diseases
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：Complete
• 页码：62-63
• 全文大小：228 K
• 卷排序：54

文摘

Typhoid fever remains a serious problem in many developing countries. Due to resistance to multiple first line drugs, azithromycin has evolved as an important drug in the treatment of typhoid. While therapy with azithromycin is highly effective, no clinically validated mean inhibitory concentration (MIC) break points or disc diffusion cutoff guidelines are available so far. We describe an Indian adult with clinical and microbiological failure to azithromycin despite low azithromycin MIC.