Does oocyte donation compared with autologous oocyte IVF pregnancies have a higher risk of preeclampsia?

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• 作者：Theoni B. Tarlatzi^a ; ^{nonika.tarlatzi@gmail.com} ; ^{theoni.tarlatzi@erasme.ulb.ac.be}Author Vitae ; Romain Imbert^a ; ¹ ; Beatriz Alvaro Mercadal^a ; ² ; Isabelle Demeestere^b ; Christos A. Venetis^c ; Yvon Englert^a ; Anne Delbaere^a
• 关键词：neonatal outcomes ; obstetric outcomes ; oocyte donation ; preeclampsia ; pregnancy-induced hypertension
• 刊名：Reproductive BioMedicine Online
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：34
• 期：1
• 页码：11-18
• 全文大小：453 K
• 卷排序：34

文摘

The aim of this study was to evaluate whether pregnancies resulting from oocyte donation have a higher risk of preeclampsia compared with pregnancies after IVF using autologous oocytes. Propensity score matching on maternal age and parity was carried out on a one to one basis, and a total of 144 singleton pregnancies resulting in delivery beyond 22 gestational weeks, achieved by oocyte donation, were compared with 144 pregnancies achieved through IVF and intracytoplasmic sperm injection with the use of autologous oocytes. All pregnancies were achieved after fresh embryo transfer. Obstetric and neonatal outcomes were compared for each pregnancy. Singleton pregnancies after oocyte donation were associated with a significantly higher risk for preeclampsia (OR 2.4, CI 1.02 to 5.8; P = 0.046), as well as for pregnancy-induced hypertension (OR 5.3, CI 1.1 to 25.2; P = 0.036), and caesarean delivery (OR 2.3, CI 1.4 to 3.7; P = 0.001) compared with pregnancies using autologous oocytes.