Antimicrobial activity of novel 4H-4-oxoquinolizine compounds against extensively drug-resistant Acinetobacter baumannii strains

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• 作者：Seok Hyeon Na^a ; Hyejin Jeon^a ; Yoo Jeong Kim^a ; Hyo Il Kwon^a ; Gati Noble Selasi^a ; Asiimwe Nicholas^a ; Chang-Soo Yun^b ; Sang Ho Lee^b ; Je Chul Lee^a ; ^{leejc@knu.ac.kr}
• 关键词：4H-4-oxoquinolizine ; Fluoroquinolone ; Antimicrobial resistance ; DNA gyrase inhibitor ; Chemical compound
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：1
• 页码：107-111
• 全文大小：370 K
• 卷排序：49

文摘

Development of new antimicrobials for drug-resistant Acinetobacter baumannii is urgently needed. 4H-4-oxoquinolizines were screened against A. baumannii ATCC 17978 by HTS analysis. Novel 4H-4-oxoquinolizines were extremely active against XDR A. baumannii isolates. Novel 4H-4-oxoquinolizines were active against fluoroquinolone-resistant A. baumannii.