SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens

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• 作者：Esther Herpel ; MD^a ; Ralf J. Rieker ; MD^b ; Hendrik Dienemann ; MD^c ; ^e ; Thomas Muley ; PhD^d ; ^e ; Michael Meister ; PhD^d ; ^e ; Arndt Hartmann ; MD^b ; Arne Warth ; MD^a ; ^e ; Abbas Agaimy ; MD^b ; ^{abbas.agaimy@uk-erlangen.de}
• 关键词：SWI/SNF complex ; SMARCA4 ; SMARCA2 ; NSCLC ; Adenocarcinoma ; Squamous cell carcinoma
• 刊名：Annals of Diagnostic Pathology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：26
• 期：Complete
• 页码：47-51
• 全文大小：1337 K
• 卷排序：26

文摘

SMARCA4 and SMARCA2 deficiency is observed in 10% of consecutive NSCLC cases. In contrast to SWI/SNF-deficient carcinomas from other organs, differentiated (glandular or squamous) histology is frequent in SWI/SNF-deficient pulmonary carcinomas. SMARCA4 and SMARCA2 should be included in the workup of TTF1-negative adenocarcinoma of presumable pulmonary origin as 80% of SMARCA4/SMARCA2-deficient lung adenocarcinomas are TTF1 negative. Given the recently reported potential role of SMARCA4 loss as a predictor of chemosensitivity to platinum-based chemotherapy in resected NSCLC, recognition of SMARCA4-deficient NSCLC in routine surgical pathology practice is recommended.