Intravenous electrical vagal nerve stimulation prior to coronary reperfusion in a canine ischemia-reperfusion model markedly reduces infarct size and prevents subsequent heart failure

详细信息    查看全文

• 作者：Takahiro Arimura^a ; ^{arimurat@cardiol.med.kyushu-u.ac.jp} ; Keita Saku^b ; ^{saku@cardiol.med.kyushu-u.ac.jp} ; Takamori Kakino^a ; ^{kakino-t@cardiol.med.kyushu-u.ac.jp} ; Takuya Nishikawa^a ; ^{nisikawa@cardiol.med.kyushu-u.ac.jp} ; Takeshi Tohyama^a ; ^{tohyama@cardiol.med.kyushu-u.ac.jp} ; Takafumi Sakamoto^a ; ^{tsaka@cardiol.med.kyushu-u.ac.jp} ; Kazuo Sakamoto^a ; ^{kazuos@cardiol.med.kyushu-u.ac.jp} ; Takuya Kishi^c ; ^{tkishi@cardiol.med.kyushu-u.ac.jp} ; Tomomi Ide^a ; ^{tomomi_i@cardiol.med.kyushu-u.ac.jp} ; Kenji Sunagawa^b ; ^{sunagawa@cardiol.med.kyushu-u.ac.jp}
• 关键词：AAI ; atrial pacing and sensing mode ; AMI ; acute myocardial infarction ; ANOVA ; one-way factorial analysis of variance ; AP ; arterial pressure ; Ees ; end-systolic elastance ; ELISA ; enzyme-linked immunosorbent assays ; ESPVR ; end-systolic pressure&ndash ; volume relationship ; HR ; heart rate ; I/R ; ischemia&ndash ; reperfusion ; iVNS ; intravenous vagal nerve stimulation ; LAD ; left anterior descending coronary artery ; LCX ; left circumflex coronary artery ; LAP ; left atrial pressure ; LV ; left ventricle ; LVEDV
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：227
• 期：Complete
• 页码：704-710
• 全文大小：806 K
• 卷排序：227

文摘

In an ischemia-reperfusion canine model, iVNS markedly reduced infarct size and preserved LV function one month later. The bradycardic effect plays an important role in the beneficial effect of iVNS. Intravenous VNS may be a novel therapeutic strategy and contribute to improve the long-term survival in patients with AMI.