Obstructive sleep apnoea is frequent in patients with type 1 diabetes

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• 作者：Anne Margareta Banghoej^a ; ^{anne.margareta.banghoej@regionh.dk} ; Henriette Holst Nerild^a ; Peter Lommer Kristensen^a ; Ulrik Pedersen-Bjergaard^a ; ^e ; Jesper Fleischer^b ; Andreas Emil Kryger Jensen^c ; Michael Laub^d ; Birger Thorsteinsson^a ; ^e ; Lise Tarnow^a ; ^b
• 关键词：Type 1 diabetes ; Obstructive sleep apnoea ; Diabetic complications ; Apnoea&ndash ; hypopnea index ; Sleepiness
• 刊名：Journal of Diabetes and its Complications
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：31
• 期：1
• 页码：156-161
• 全文大小：426 K
• 卷排序：31

文摘

Obstructive Sleep Apnoea (OSA) is frequent in patients with type 2 diabetes. The aim of this study is to evaluate prevalence of OSA in patients with type 1 diabetes.MethodsIn a cross-sectional design, all patients with type 1 diabetes attending the outpatient clinic were offered screening for OSA for one night with the ApneaLink + home-monitoring device. OSA was classified by the Apnoea–Hypopnea index (AHI; apnoeas/hypopneas per hour sleep). Symptoms of OSA were scored using the Epworth Sleepiness Score. Presence of autonomic neuropathy was evaluated by the Vagus® device.ResultsA total of 200 of 518 eligible patients with type 1 diabetes (39%) participated (68% men; age 52 ± 15 years (mean ± SD), diabetes duration 24 ± 14 years and BMI 25.3 ± 3.3 kg/m2). OSA was diagnosed in 92 patients (46% (95% CI: 40–53)). Five patients had known OSA, and OSA was newly diagnosed in 87 patients, predominantly mild OSA (60 patients (69%)).OSA was present in 32% of the patients with normal BMI, in 60% of overweight patients, and in 61% of obese patients. Patients with type 1 diabetes and OSA were largely asymptomatic and did not report more sleepiness than patients without OSA. At multivariate analysis, age, BMI and presence of nephropathy were positively associated with risk of OSA.ConclusionsThe prevalence of asymptomatic OSA is high in a cohort of patients with type 1 diabetes. Older age, overweight, and presence of nephropathy are associated with OSA.