Small-molecule inhibitors of Ataxia Telangiectasia and Rad3 related kinase (ATR) sensitize lymphoma cells to UVA radiation

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• 作者：Edyta Biskup ; PhD^a ; ^{edyta.biskup@gmail.com} ; David Gram Naym ; MSc^a ; Robert Gniadecki^a ; ^b ; ^c (DMSc prof. of dermatology)
• 关键词：ATR inhibitors ; VE-821 ; VE-822 ; Cutaneous T-cell lymphoma ; DNA damage
• 刊名：Journal of Dermatological Science
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：84
• 期：3
• 页码：239-247
• 全文大小：1911 K
• 卷排序：84

文摘

Chemical inhibitors of Ataxia Telangiectasia and Rad 3 kinase (ATR), VE-821 and VE-822, potently sensitize cutaneous T-cell lymphoma cells to UVA radiation. The synergism between VE-821/2 and UVA is not solely caused by specific blocking of ATR kinase, but also due to ATR-independent photosensitization. ATR inhibitors have potential to be used as photosensitizers in photochemotherapeutic regimes for cutaneous lymphomas.