Electric field-induced suppression of PTEN drives epithelial-to-mesenchymal transition via mTORC1 activation

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• 作者：Tiantian Yan^a ; Xupin Jiang^a ; Xiaowei Guo^b ; Wen Chen^c ; Di Tang^a ; Junhui Zhang^a ; Xingyue Zhang^a ; Dongxia Zhang^a ; Qiong Zhang^a ; Jiezhi Jia^a ; Yuesheng Huang^a ; ^{yshuangtmmu@163.com}
• 关键词：Electric fields ; Epithelial-to-mesenchymal transition ; Keratinocyte ; Migration ; PTEN ; mTORC1
• 刊名：Journal of Dermatological Science
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：85
• 期：2
• 页码：96-105
• 全文大小：4782 K
• 卷排序：85

文摘

We demonstrate that EFs can induce the EMT in keratinocytes for the first time, providing novel perspectives of the significance of EFs in wound healing. EF-induced suppression of PTEN drives the EMT acquisition. mTORC1 is required for EF-induced EMT and enhanced migratory capacity. mTORC1 is involved in the EMT driven by PTEN suppression.