Simplifying study of fever's dramatic relief of autistic behavior

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• 作者：Peter Good ^{autismstudies1@gmail.com}
• 关键词：Autism ; Fever ; Benefit ; Glutamine ; Taurine ; Water ; Myelin ; Astrocytes ; Blood
• 刊名：Clinical Nutrition ESPEN
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：17
• 期：Complete
• 页码：1-7
• 全文大小：709 K
• 卷排序：17

文摘

Dramatic relief of autistic behavior by infectious fever continues to tantalize parents and practitioners, yet researchers still hesitate to study its physiology/biochemistry, fearing stress and heat of brain imaging, contagion, and fever's complexity. Yet what could be more revealing than a common event that virtually ‘normalizes’ autistic behavior for a time? This paper proposes study of three simplified scenarios: (1) improvements appearing hours before fever, (2) return of autistic behavior soon after fever, (3) improvements persisting long after fever. Each scenario limits some risk – and some explanation – inviting triangulation of decisive factor(s) in relief and recurrence. Return of autistic behavior after fever may be most revealing. The complex mechanisms that generated fever have all abated; simpler cooling mechanisms prevail – how many plausible explanations can there be? The decisive factor in fever's benefit is concluded to be water drawn/carried from brain myelin and astrocytes by osmolytes glutamine and taurine released from muscles and brain; the decisive factor in return of autistic behavior after fever is return of water.