Anti-biofilm activity against Staphylococcus aureus MRSA and MSSA of neolignans and extract of Piper regnellii

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• 作者：Lara Z.S. Brambilla^a ; Eliana H. Endo^a ; Dió ; genes A.G. Cortez^b ; Benedito P. Dias Filho^a ; ^{bpdfilho@uem.br}
• 关键词：Biofilm ; Conocarpan ; Dichloromethane extract ; Eupomathenoid-5 ; Staphylococcus aureus
• 刊名：Revista Brasileira de Farmacognosia
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：27
• 期：1
• 页码：112-117
• 全文大小：785 K
• 卷排序：27

文摘

Many infections worldwide are associated with bacterial biofilms. The effects of isolated neolignans (conocarpan and eupomathenoid-5) and the dichloromethane extract of Piper regnellii (Miq.) C. DC., Piperaceae, were tested against isolates of methicillin-resistant Staphylococcus aureus and methicillin-sensitive S. aureus biofilms and S. aureus planktonic cells. The dichloromethane extract presented better results than isolated neolignans against all of the biofilms tested, with a minimum inhibitory concentration <400 μg/ml for preformed biofilms and minimal biofilm inhibitory concentration of 15.6 μg/ml for biofilm formation. The minimum inhibitory concentration to planktonic cells was <12.5 μg/ml. These results indicate a good effect of the dichloromethane extract against methicillin-resistant S. aureus and methicillin-sensitive S. aureus biofilms and efficient prophylaxis.