Real-time US-CT/MR fusion imaging for percutaneous radiofrequency ablation of hepatocellular carcinoma

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• 作者：Su Joa Ahn¹ ; Jeong Min Lee¹ ; ² ; ^{jmsh@snu.ac.kr} ; Dong Ho Lee¹ ; Sang Min Lee¹ ; Jung-Hwan Yoon³ ; Yoon Jun Kim³ ; Jeong-Hoon Lee³ ; Su Jong Yu³ ; Joon Koo Han¹ ; ²
• 关键词：Hepatocellular carcinoma ; Radiofrequency ablation ; Imaging guidance ; Real-time fusion imaging ; Risk of recurrence ; Local tumor progression
• 刊名：Journal of Hepatology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：66
• 期：2
• 页码：347-354
• 全文大小：1238 K
• 卷排序：66

文摘

Although ultrasonography (US) guided radiofrequency ablation (RFA) is a commonly used treatment option for early hepatocellular carcinoma (HCC), inconspicuous tumors on US limits its feasibility. Thus, we prospectively determined whether real-time US-CT/MR fusion imaging can improve the technical feasibility of RFA compared with B-mode US, and help predict local tumor progression after RFA in patients with HCC.MethodsA total of 216 patients with 243 HCCs ⩽5 cm referred for RFA were prospectively enrolled. Prior to RFA, the operators scored the visibility of tumors, and technical feasibility on a 4-point scale at both B-mode US and fusion imaging. RFA was performed with a switching monopolar system using a separable cluster electrode under fusion imaging guidance. Technique effectiveness, local tumor progression and intrahepatic remote recurrences were evaluated.ResultsTumor visibility and technical feasibility were significantly improved with fusion imaging compared with B-mode US (p <0.001). Under fusion imaging guidance, the technique effectiveness of RFA for invisible tumors on B-mode US was similar to those for visible tumors (96.1% vs. 97.6%, p = 0.295). Estimated cumulative incidence of local tumor progression at 24 months was 4.7%, and previous treatment for other hepatic tumors (p = 0.01), higher expected number of electrode insertions needed and lower technical feasibility scores (p <0.01) on fusion imaging were significant negative predictive factors for local tumor progression.ConclusionReal-time fusion imaging guidance significantly improved the tumor visibility and technical feasibility of RFA in patients with HCCs compared with B-mode US, and low feasibility scores on fusion imaging was a significant negative predictive factor for local tumor progression.Lay summaryUS/CT-MR fusion imaging guidance improved the tumor visibility and technical feasibility of RFA in patients with HCCs. In addition, fusion imaging guided RFA using multiple electrodes demonstrated a high technique effectiveness rate and a low local tumor progression rate during mid-term follow-up.Clinical trial number: ClinicalTrials.gov number, NCT02687113.