Estrogen receptor activation by tobacco smoke condensate in hormonal therapy-resistant breast cancer cells

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• 作者：Toshifumi Niwa^a ; ^{niwa@med.tohoku.ac.jp} ; Yuri Shinagawa^a ; Yosuke Asari^a ; Kanae Suzuki^a ; Junko Takanobu^a ; Tatsuyuki Gohno^a ; Yuri Yamaguchi^b ; Shin-ichi Hayashi^a ; ^c
• 关键词：TSC ; tobacco smoke condensate ; ER ; estrogen receptor ; EDR cells ; estrogen depletion-resistant cells ; E2 ; estradiol ; ERE ; estrogen-responsive element ; GFP ; green fluorescent protein ; AI ; aromatase inhibitors ; Tam ; 4-hydroxytamoxifen ; Ful ; fulvestrant ; B[a]A ; benz[a]anthracene ; B[a]P ; benzo[a]pyrene ; NNK ; 4-(methylnitrosoamoino)-1-(3-pyridyl)-1-butanone ; NNN ; N'-nitrosonornicotine
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：165
• 期：part_PB
• 页码：448-457
• 全文大小：1308 K
• 卷排序：165

文摘

Effect of tobacco smoke condensate on estrogen receptor activity was examined. TSC significantly activated ERs, and upregulated its endogenous target genes. ER activation was inhibited by fulvestrant and weakly inhibited by tamoxifen. TSC activates ER by both ligand-dependent and – independent mechanisms. Tobacco smoke may interfere with hormonal therapy for breast cancer.