Molecular cloning and characterization of hagfish estrogen receptors

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• 作者：Osamu Nishimiya^a ; Yoshinao Katsu^b ; Hiroyuki Inagawa^c ; Naoshi Hiramatsu^a ; Takashi Todo^a ; ^{todo@fish.hokudai.ac.jp} ; Akihiko Hara^a
• 关键词：Agnathan ; Eptatretus burgeri ; Estrogen receptor ; Molecular cloning ; Transactivation
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：165
• 期：part_PB
• 页码：190-201
• 全文大小：1981 K
• 卷排序：165

文摘

Liver-derived cDNAs encoding estrogen receptors (er1 and er2) were cloned from inshore hagfish. Phylogenetic analysis placed hagfish ER1 into a position prior to the divergence of vertebrate ERs. Hagfish ER2 is considered to be the ancestor of ERβ. Tissue distribution patterns of both er mRNAs were different. Estrogen responsive-luciferase reporter assay confirmed that both ERs are functional.