Human cytomegalovirus infection downregulates vitamin-D receptor in mammalian cells

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• 作者：Franz J.J. Rieder^a ; Charlotte Grö ; schel^b ; Marie-Theres Kastner^a ; Karin Kosulin^c ; Johannes Laengle^d ; Rene Zadnikar^e ; Rodrig Marculescu^e ; Martina Schneider^a ; Thomas Lion^c ; ^f ; Michael Bergmann^d ; Enikö ; Kallay^b ; Christoph Steininger^a ; ^{christoph.steininger@meduniwien.ac.at}
• 关键词：Human cytomegalovirus (CMV) ; Vitamin D receptor ; Calcitriol ; EB-1089 ; CYP24A1 ; CYP27B1
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：165
• 期：part_PB
• 页码：356-362
• 全文大小：965 K
• 卷排序：165

文摘

Vitamin D is essential for the human body including antimicrobial responses. Cytomegalovirus infection downregulates VDR expression in vitro.. Expression of CYP24A1 decreases and of CYP27B1 increases in parallel. VDR expression is not downregulated during influenza virus or adenovirus replication. Cytomegalovirus may also influence VDR expression in vivo.