Lessons from tissue compartment-specific analysis of androgen receptor alterations in prostate cancer

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• 作者：Mark Daniel^a ; ^b ; Scott M. Dehm^b ; ^c ; ^d ; ^dehm@umn.edu
• 关键词：LHRH ; luteinizing hormone releasing hormone ; ADT ; androgen depletion therapy ; CRPC ; castration-resistant prostate cancer ; CYP17 ; cytochrome P450 c17 ; MR ; mineralocorticoid receptor ; ER ; estrogen receptor ; PR ; progestins receptor ; GR ; glucocorticoid receptor ; NTD ; NH2-terminal domain ; AF-1 ; activation function 1 ; LBD ; ligand bind domain ; ARE ; androgen response element ; RIP ; RNA co-immunoprecipitation ; NCOA ; nuclear receptor coactivator ; NCOR ; nuclear receptor corepressor ; CTC ; circulating tumor c
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：166
• 期：Complete
• 页码：28-37
• 全文大小：977 K
• 卷排序：166

文摘

Reactivation of androgen receptor is critical in prostate cancer disease progression. Androgen receptor splice variants lack the COOH-terminal ligand binding domain rendering them constitutively active in the absence of ligand. Androgen receptor splice variant transcripts are detectable in multiple tissue compartments. Androgen receptor splice variant-7 may serve as a predictive biomarker for patients treated with androgen receptor targeted therapies.