Prognostic Value of Insulin-Like Growth Factor-Binding Protein 7 in Patients with Heart Failure and Preserved Ejection Fraction

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• 作者：Parul U. Gandhi ; MD¹ ; ² ; Sheryl L. Chow ; PharmD³ ; Thomas S. Rector ; PhD⁴ ; ⁵ ; Henry Krum ; PhD FRACP⁶ ; Hanna K. Gaggin ; MD ; MPH⁷ ; John J. McMurray ; MD⁸ ; Michael R. Zile ; MD⁹ ; Michel Komajda ; MD¹⁰ ; Robert S. McKelvie ; MD ; PhD¹¹ ; Peter E. Carson ; MD¹² ; James L. Januzzi Jr. ; MD⁷ ; ^* ; ^{jjanuzzi@partners.org} ; Inder S. Anand ; MD ; DPhil⁴ ; ⁵ ; ^*
• 关键词：Heart failure ; biomarkers ; preserved left ventricular function ; prognosis ; insulin-like growth factor-binding protein 7
• 刊名：Journal of Cardiac Failure
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：23
• 期：1
• 页码：20-28
• 全文大小：275 K
• 卷排序：23

文摘

Insulin-like growth factor-binding protein 7 (IGFBP7) was correlated with age, amino-terminal pro-B-type NP (NT-proBNP), and renal function in patients with heart failure and preserved ejection fraction (HFpEF). Baseline IGFBP7 was prognostic in patients with HFpEF with regard to all-cause mortality, cardiovascular hospitalization, and a composite of HF hospitalization or HF death; higher concentrations are associated with elevated risk. Baseline IGFBP7 remained a significant predictor after adjustment for NT-proBNP and renal function, but lost significance in the fully adjusted model. Further studies are needed to understand the relationship between IGFPB7 and HFpEF.