Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and head and neck cancers risk

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• 作者：Francesca Bravi^a ; ^{francesca.bravi@marionegri.it} ; ^{francesca.bravi@unimi.it} ; Jerry Polesel^b ; Werner Garavello^c ; Diego Serraino^b ; Eva Negri^a ; Gianni Franchin^d ; Carlo La Vecchia^e ; Cristina Bosetti^a
• 关键词：AICR ; American Institute for Cancer Research ; BMI ; body mass index ; CI ; confidence interval ; EPIC ; European Prospective Investigation into Nutrition and Cancer ; FFQ ; food frequency questionnaire ; INHANCE ; International Head and Neck Cancer Epidemiology ; OCP ; oral cavity and pharyngeal ; OR ; odds ratios ; WCRF ; World Cancer Research Fund
• 刊名：Oral Oncology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：64
• 期：Complete
• 页码：59-64
• 全文大小：335 K
• 卷排序：64

文摘

The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) have proposed eight recommendations for cancer prevention, related to body fatness, diet, and physical activity. Our aim is to evaluate the role of adherence to these recommendations on head and neck cancers risk.Materials and methodsWe obtained an overall score including seven of the WCRF/AICR recommendations, and examined its relationship with head and neck cancers risk in two Italian case-control studies including 946 patients with oral cavity and pharyngeal (OCP) cancer and 2492 controls, and 689 patients with laryngeal cancer and 1605 controls.ResultsHigher adherence to WCRF/AICR recommendations was associated to a reduced risk of OCP cancer (odds ratio, OR = 0.45, 95% confidence interval, CI: 0.33–0.62 for a score of 4–<5, and OR = 0.32, 95% CI: 0.22–0.49 for a score of ⩾5 as compared to <3). The ORs for laryngeal cancer were 0.68 (95% CI: 0.50–0.92) for a score of 3–<4, 0.39 (95% CI: 0.28–0.55) for a score of 4–<5, and 0.24 (95% CI: 0.15–0.38) for a score of ⩾5.ConclusionOur study indicates that high adherence to the WCRF/AICR recommendations for cancer prevention is associated with a substantially decreased risk of head and neck cancers.