Clinical Characteristics and Long-Term Outcomes of Movement Disorders in Childhood Thalamic Tumors

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• 作者：Zsila S. Sadighi ; MD^a ; ^{zsila.sadighi@stjude.org} ; Jennifer Zabrowski ; RN^a ; Frederick A. Boop ; MD^b ; ^c ; ^d ; ^e ; Alberto Broniscer ; MD^f ; Amar Gajjar ; MD^a ; ^f ; Raja B. Khan ; MD^a
• 关键词：thalamic tumors ; childhood ; movement disorder ; outcome
• 刊名：Pediatric Neurology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：65
• 期：Complete
• 页码：71-77
• 全文大小：610 K
• 卷排序：65

文摘

We studied the outcomes of movement disorders that were associated with childhood thalamic tumors.MethodsWe retrospectively reviewed 83 children with thalamic tumors treated at our institution from 1996 to 2013 to document the incidence and outcome of movement disorders. Magnetic resonance imaging was used to analyze the involvement of thalamic nuclei, and three instruments were used to rate the severity of the disorders.ResultsNine (11%) patients had one or more of the following movement disorders: postural tremor, resting tremor, ballism, dystonia, myoclonus, and athetosis. Median age at tumor diagnosis was seven years (range, 0.25 to 11 years), and the average age at movement disorder onset was eight years (range, 1.5 to 11 years). Movement disorders developed at a median of 1.5 months (range, 0 to 4 months) after surgical resection. The severity of the disorders was either unchanged or slightly improved during follow-up. The red nuclei were the only thalamic structures that showed tumor involvement in all nine patients.ConclusionsNo specific injury of the thalamic nuclei was associated with movement disorders in children with thalamic tumors, and the severity of these disorders did not change over time.