Determinants of denervation-independent depletion of putamen dopamine in Parkinson's disease and multiple system atrophy

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• 作者：David S. Goldstein^a ; ^{goldsteind@ninds.nih.gov} ; Patti Sullivan^a ; Courtney Holmes^a ; Deborah C. Mash^b ; Irwin J. Kopin^a ; Yehonatan Sharabi^c
• 关键词：Cysteinyl-dopamine ; Cysteinyl-DOPA ; Parkinson&rsquo ; s disease ; Multiple system atrophy
• 刊名：Parkinsonism & Related Disorders
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：35
• 期：Complete
• 页码：88-91
• 全文大小：335 K
• 卷排序：35

文摘

Putamen dopamine depletion typifies Parkinson's disease and multiple system atrophy. The depletion is greater than explained by nigrostriatal denervation alone. We measured putamen cysteinyl and parent catechols in both diseases. Evidence was obtained for decreased dopamine synthesis and vesicular uptake. The results indicate denervation-independent abnormalities of dopamine metabolism.